To be clear, the genes code for the markers on the cells that the genes are in and ‘switched on’ in. It is not a master control system where a gene in a cell in the brain codes for the marker to be produced in a cell in the liver!!
HLA is an abbreviation that stands for ‘Human Leucocyte Antigen’.
In plain language this means:
“protein markers on the surface of cells of people that are recognised by their own white cells” [much quicker to say ‘HLA’ really….!]
There are different classes of cell markers coded for by this HLA group of genes.
The different classes code for different types of proteins, occurring in different cells on the cell walls: and being different in size and shape, they have different functions.
The presence of these antigens as ‘read’ by the white cells determines the fate of the cell… and its fate is sealed!
Showing these ‘antigens’ on the cell wall is like raising a ‘red flag’ to the immune system: ‘killer T cells’ receive this as a message to engulf and destroy the cell, which has indicated it is infected by displaying the ‘antigen’ on its surface.
HLA–B27 is part of a group which encodes for proteins that are in the cell membrane and have the particular function of bringing peptides (broken down bits of protein) from inside the cell to the cell surface for immune cells to see. Peptides can come from ingested bacteria or viruses.